Shaanxi Cuikang Pharmaceutical Technology Co., Ltd

Oseltamivir phosphate is the drug precursor of its active metabolite, and its active metabolite (oseltamivir carboxylate) is a selective influenza virus neuraminidase inhibitor. Neuraminidase is a kind of glycoprotein on the surface of virus. Its activity is crucial for the release of newly formed virus particles from infected cells and the further spread of infectious virus in human body. The active metabolite of oseltamivir phosphate can inhibit the neuraminidase activity of influenza A and B viruses. In vitro, the half inhibitory concentration of viral neuraminidase activity was as low as the level of nanogram. Active metabolites were observed to inhibit the growth of influenza virus in vitro, and also to inhibit the replication and pathogenicity of influenza virus in vivo. This product reduces the spread of influenza A or B virus by inhibiting the release of virus from infected cells. Studies on naturally acquired and laboratory influenza have shown that the use of oseltamivir phosphate does not affect the normal humoral immune response of the human body to infection. Antibody responses to inactivated vaccines were not affected by oseltamivir phosphate treatment.